Upcoming Seminars

We would like to announce two seminars given by Prof. Mai Suan Li (Poland) and Dr. Trinh Thanh Thuat (Norway) next week. Please see below for detail. 

Wednesday, June 22nd, 2016

Protein Aggregation and Related Diseases

Mai Suan Li1,2, Professor of Physics

1Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, Warsaw, Poland

2 Instiute for  Computational Science and Technology at Ho Chi Minh City, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, HCM city, Vietnam

Time: 10:00AM, June 22nd, 2016 (Wednesday) <====== Newly updated time

Place: Meeting Room, Center for Innovative Materials and Architectures

            Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City

Abstract:

Protein aggregation is presumably associated with a large group of major human diseases including Alzheimer’s disease (AD), prion disorders, type 2 diabetes etc. Therefore, understanding the key factors that control this process is important not only for basic research but also for drug design for relevant diseases. The fibrillogenesis of polypeptide chains depends on their intrinsic properties as well as on external conditions. Using coarse grained and all-atom models we show that fibril formation times are strongly correlated with hydrophobicity, charges and population of the so called  fibril-prone conformation N* in  monomer state. The higher is the N* population the faster is the fibril elongation and this dependence may be described by a single exponential function. Our results open up a new way to understand the propensity of biomolecules to aggregation at  monomer level.

We will discuss the ways of blocking aggregation and destroying fibers of amyloid beta peptides the self-assembly of which is believed to be the main cause of AD. Through in silico and in vitro experiments small molecules from large data bases and short peptides have been obtained as potential candidates for treating AD due to their strong binding to  amyloid beta aggregates. Picosecond dissociation of amyloid fibrils with infrared laser will be discussed. Nonequilibrium simulation studies show that the fibril is destroyed due to the strong resonance between its amide I vibrational modes and the laser field, not just the deposited infrared thermal energy.

$11.     J. Nasica-Labouze, M. S. Li et al, Chem Rev 115, 3518-3563 (2015)

$12.     M.S. Li, N.T Co, , G. Reddy, C-K Hu and D. Thirumalai, Phys. Rev. Lett. 105, 218101 (2010)

$13.     P. M. Truong, M.H. Viet,  P.H. Nguyen, C. K. Hu, and M.S. Li, J. Phys. Chem. B 118, 8972 (2014)

$14.     P.D.Q. Huy and M.S. Li, Phys. Chem. 16, 20030-20040 (2014)

$15.     M. H. Viet, C-Y. Chen, C-K. Hu, Y-R. Chen, and M.S. Li, Plos One 8(11), e79151 (2013)

$16.     M.H. Viet, S.T. Ngo, N.S. Lam , and M.S. Li,  J. Phys. Chem. B 115, 7433 (2011)

$17.     M.H. Viet, K. Siposova, Z. Bednarikova, A. Antosova, T.T. Nguyen, Z. Gazova, and M.S. Li, J. Phys. Chem. B 119, 5145 (2015).

 F

F     Friday, June 24th, 2016

A    Adsorption and separation of gas mixture CO2, CH4, N2 in UTSA-16 MOF by computer simulation

N    Trinh Thanh Thuat1, Ph.D.; Sondre Schnell2, Professor 

1     1Department of Chemistry, Norwegian University of Science and Technology 

2     2Department of Chemistry and Materials Technology, Norwegian University of Science and Technology

       Time: 10:00AM, June 24th, 2016 (Friday)

P     Place: Meeting Room, Center for Innovative Materials and Architectures

                   Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City

         Abstract: 

      UTSA-16 is one of a promising MOF material for CO2 capture. In this talk, we present Grand Canonical Monte Carlo (GCMC) simulations of gas adsorption in UTSA-16. The important of partial charge model of MOF will be highlighted. The simulated adsorption isotherm in excellent agreement with experimental data. CO2 separation from mixture of CH4 and N2 will also be addressed in the talk. this talk will open a possible collaboration with Center for Innovative Materials and Architectures on combining experimental and computer simulation for gas adsorption and separation of MOF material. 

New name of the center

From May 8, 2016 The Center for Molecular and NanoArchitecture (MANAR) has a new name: Center for Innovative Materials and Architectures (INOMAR)

Prof. Seiji Iwasa, Toyohashi University of Technology, visits our Center

On Wednesday, 06th April, 2016, Prof. Seiji Iwasa, Toyohashi University of Technology, visits MANAR. Our researchers introduce the general research activities, our recently achievements and some research fields in future. We also took him to a tour of our state-of-the-art facilities and laboratories. The professor is very interested in our research and gives some new ideas for our research. We thank him for visiting our center and valuable discussions. We hope our center and his university will have colaboration in future!

MANAR publication is among the 2016 Journal of Materials Chemistry A Hot Papers

Thach N. Tu's paper "High proton conductivity at low relative humidity in an anionic Fe-based metal–organic framework" has been selected into part of themed collection: 2016 Journal of Materials Chemistry A Hot Papers. Congratulations to all the authors whose article are featured! Link:

Read more: MANAR publication is among the 2016 Journal of Materials Chemistry A Hot Papers

Representatives of ONRG visited MANAR

On Monday, 14th March, 2016, Dr. Andrew Higier, Associate Director of U.S. Office of Naval Research Global (ONR Global) and Dr. Ashok Patil, Director of Power and Energy Collaboration, U.S. Army RDECOM come to MANAR. Our researchers presented the general research activities, our recently achievements and some research fields in future. We also take them to a tour of our state-of-the-art facilities and laboratories. We thank them for visiting our center and their continued support of MANAR and chemistry in Vietnam!   
 

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